ORR (confirmed PR) was 50% (6/12; 95% CI: 21.1‒78.9). Disease control rate (DCR) was 91.7% (11/12; 95% CI: 61.5–99.8). 5 pts had best response of SD and 1 patient had PD. Median PFS was 8.7 months (95% CI: 4.1, NE). Median overall survival (OS) was not reached, and OS rate was 100% at 6 months....KN046 combined with platinum-based chemotherapy is well tolerated and has demonstrated promising, albeit preliminary anti-tumor activity as 1L treatment for stage IV NSCLC pts with resistant oncogenic driver alterations (including EGFR and HER2 exon 20 insertion mutation, EGFR amplification, RET fusion).