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Association details:
| Biomarker: | EGFR exon 19 deletion + EGFR T790M |
|---|---|
| Cancer: | Small Cell Lung Cancer |
| Drug: | etoposide oral (Topoisomerase II inhibitor, DNA inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Gastric metastasis and transformation of primary lung adenocarcinoma to small cell cancer after acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors: A case report
Published date:
10/01/2021
Excerpt:
A 58-year-old male patient was treated with gefitinib (0.25 g /day) as the 1st line treatment due of recurrence after surgical resection for EGFR exon 19 mutation pulmonary adenocarcinoma. However, he experienced recurrence with positive T790M...The patient was treated with etoposide and platinum chemotherapy and maintenance therapy with osimertinib. Finally, the patient achieved a partial response after 4 cycles.
DOI:
10.1097/MD.0000000000027289
