^
Association details:
| Biomarker: | EGFR exon 19 deletion + EGFR L861Q + EGFR G873E |
|---|---|
| Cancer: | Non Small Cell Lung Cancer |
| Drug: | gefitinib (EGFR inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Impact of Epidermal Growth Factor Receptor and KRAS Mutations on Clinical Outcomes in Previously Untreated Non–Small Cell Lung Cancer Patients: Results of an Online Tumor Registry of Clinical Trials
Excerpt:
The genotype and clinical outcomes of patients with rarer mutation or multiple mutations are listed in Table 3. Some of these include mutations known to be associated with sensitivity (L861Q) or resistance (exon 20 insertions) to EGFR-TKI. Other mutations or combinations of mutations, however, occur much less frequently.
DOI:
10.1158/1078-0432.CCR-09-0888
