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Association details:
| Biomarker: | EGFR E746_T751delinsl |
|---|---|
| Cancer: | Non Small Cell Lung Cancer |
| Drug: | erlotinib (EGFR inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
EGF receptor gene mutations are common in lung cancers from “never smokers” and are associated with sensitivity of tumors to gefitinib and erlotinib
Excerpt:
…we performed mutational profiling of exons 18-24 of EGFR in tumors from 10 patients who demonstrated a partial response or marked clinical improvement (defined in Supporting Text) when treated with the drug as a single-agent at the Memorial Sloan-Kettering Cancer Center.... The del E746-T751insI mutation may have resulted from a double deletion of nucleotides 2229-2236 and 2245-2252 and an insertion of a single T nucleotide (Fig. 1 A and B)....Characteristics of patients sensitive to gefitinib (G) and erlotinib (E).
DOI:
10.1073/pnas.0405220101
