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Association details:
| Biomarker: | EGFR E746_A750del |
|---|---|
| Cancer: | Non Small Cell Lung Cancer |
| Drug: | Tagrisso (osimertinib) (EGFR inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Efficacy of osimertinib in patients with lung cancer positive for uncommon EGFR exon 19 deletion mutations
Published date:
03/13/2023
Excerpt:
In our multi-institution cohort (N=200), E746_A750del was associated with significantly prolonged progression free survival (PFS) with 1L osimertinib versus L747_A750>P [median 21.3 months (95% confidence interval, 17.0-31.7) vs. 11.7 months (10.8-29.4); adjusted HR 0.52 (0.28-0.98); P = 0.043].
DOI:
https://doi.org/10.1158/1078-0432.CCR-22-3497
