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Association details:
| Biomarker: | EGFR E746_A750del |
|---|---|
| Cancer: | Non Small Cell Lung Cancer |
| Drug: | pamvatamig (MCLA-129) (EGFR inhibitor, c-MET inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
The bispecific antibody MCLA-129 impairs NSCLC tumor growth by targeting EGFR and c-MET, inhibiting ligand-induced signaling and promoting ADCC and ADCP
Published date:
03/10/2021
Excerpt:
Significant tumor regression was observed following treatment of immunodeficient xenograft NSG-hHGFki mice bearing orthotopic tumors established from HCC827EGFR del (E746, A750) cells.
