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Association details:
Biomarker:EGFR E709Q
Cancer:Non Small Cell Lung Cancer
Drug:gefitinib (EGFR inhibitor)
Direction:Sensitive
Evidence:
Evidence Level:
Sensitive: C3 – Early Trials
New
Title:

Mutation in the Tyrosine Kinase Domain of Epidermal Growth Factor Receptor Is a Predictive and Prognostic Factor for Gefitinib Treatment in Patients with Non–Small Cell Lung Cancer

Excerpt:
Of the 33 patients with tumors positive for mutant EGFR, 4 patients had disease progression within 2 months of gefitinib treatment. All these tumors were squamous cell carcinoma and the patterns of mutation were delA767_V769 (exon 20), A763V mutation (exon 20), L858R mutation (exon 21), and a double substitution mutation, G719S and L861Q, in exons 18 and 21.
DOI:
10.1158/1078-0432.CCR-04-1981