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    Association details:
    Biomarker:EGFR E709G
    Cancer:Non Small Cell Lung Cancer
    Drug:gefitinib (EGFR inhibitor)
    Direction:Resistant
    Evidence:
    Evidence Level:
    Resistant: D – Preclinical
    New
    Source:
    Oncogene
    Title:

    Distinctive activation patterns in constitutively active and gefitinib-sensitive EGFR mutants

    Excerpt:
    Cells expressing S768I and E709G mutant were actually more resistant to gefitinib than cells expressing the wild-type receptor…
    DOI:
    10.1038/sj.onc.1209159