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Association details:
| Biomarker: | EGFR D770_N771insGT + EGFR V774_C775insHV |
|---|---|
| Cancer: | Non Small Cell Lung Cancer |
| Drug: | erlotinib (EGFR inhibitor) |
| Direction: | Resistant |
Evidence:
Source:
Title:
EGFR Exon 20 Insertion Mutations in Lung Adenocarcinomas: Prevalence, Molecular Heterogeneity, and Clinicopathologic Characteristics
Excerpt:
1 patient with A763_Y764insFQEA was treated with erlotinib in combination with chemotherapy and had partial response; 1 patient with V774_C775insHV was treated with a combination of chemotherapy and gefitinib with partial response followed by 1 year of erlotinib maintenance prior to disease progression, at which time he was switched to neratinib without benefit; 2 patients with D770_N771insGT and V774_C775insHV were treated with erlotinib as single agent with no response.
DOI:
10.1158/1535-7163.MCT-12-0620
