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Association details:
| Biomarker: | EGFR C797S + EGFR T790M + EGFR L858R |
|---|---|
| Cancer: | Non Small Cell Lung Cancer |
| Drug: | 14aj (EGFR inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Discovery and structural optimization of potent epidermal growth factor receptor (EGFR) inhibitors against L858R/T790M/C797S resistance mutation for lung cancer treatment
Published date:
04/18/2022
Excerpt:
In vitro assays, compound 14aj exhibited high potency against NSCLC cells harboring EGFRL858R/T790M/C797S and induced tumor cell cycle arrest and cell apoptosis….In vivo xenograft mouse model, oral administration of compound 14aj led to significant tumor regression without obvious toxicity.
DOI:
https://doi.org/10.1016/j.ejmech.2022.114381
