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Association details:
| Biomarker: | EGFR A763_Y764insFQEA |
|---|---|
| Cancer: | Lung Adenocarcinoma |
| Drug: | Tagrisso (osimertinib) (EGFR inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
EGFR-A763_Y764insFQEA Is a Unique Exon 20 Insertion Mutation That Displays Sensitivity to Approved and In-Development Lung Cancer EGFR Tyrosine Kinase Inhibitors
Excerpt:
We further confirmed these findings using patient-derived lung adenocarcinoma cell lines. The EGFR-A763_Y764insFQEA-bearing BID007 cells were more sensitive to erlotinib, afatinib, and osimertinib…
DOI:
https://doi.org/10.1016/j.jtocrr.2020.100051
