^
Association details:
Biomarker:EGFR 181946 C>T
Cancer:Non Small Cell Lung Cancer
Drug:gefitinib (EGFR inhibitor)
Direction:Resistant
Evidence:
Evidence Level:
Resistant: C3 – Early Trials
Title:

Clinical implications of germline variations for treatment outcome and drug resistance for small molecule kinase inhibitors in patients with non-small cell lung cancer

Published date:
04/05/2022
Excerpt:
The polymorphism 181946 C>T in the EGFR gene has also been investigated for gefitinib treatment....Two of three studies did find significant decreases in PFS and OS...
DOI:
https://doi.org/10.1016/j.drup.2022.100832