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Association details:
Evidence:
Evidence Level:
Sensitive: D – Preclinical
New
Title:

Comprehensive Predictive Biomarker Analysis for MEK Inhibitor GSK1120212

Excerpt:
In addition, a proportion of cell lines from certain tissue types not known to carry frequent RAF/RAS mutations also seemed to be sensitive to GSK1120212. Among these were breast cancer cell lines, with triple negative breast cancer cell lines being more sensitive than cell lines from other breast cancer subtypes. We identified a single gene DUSP6, whose expression was associated with sensitivity to GSK1120212...
DOI:
10.1158/1535-7163.MCT-11-0505