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Association details:
| Biomarker: | DPEP3 overexpression |
|---|---|
| Cancer: | Ovarian Cancer |
| Drug: | tamrintamab pamozirine (SC-003) (DNA replication inhibitor, DPEP3-targeted antibody-drug conjugate) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Tamrintamab pamozirine (SC-003) in patients with platinum-resistant/refractory ovarian cancer: Findings of a phase 1 study
Excerpt:
Patients with DPEP3-positive tumors were enrolled in the dose-expansion phase of the study and treated with SC-003 monotherapy or in combination with budigalimab….Post-hoc examination of antitumor activity suggested a higher response rate in patients with higher DPEP3 expression.
DOI:
https://doi.org/10.1016/j.ygyno.2020.05.038
