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Association details:
| Biomarker: | DOT1L overexpression |
|---|---|
| Cancer: | Multiple Myeloma |
| Drug Class: | DOT1L inhibitor |
| Direction: | Sensitive |
Evidence:
Source:
Title:
DOT1L inhibition blocks multiple myeloma cell proliferation by suppressing IRF4-MYC signaling
Excerpt:
DOT1L expression levels were higher in monoclonal gammopathy of undetermined significance and smoldering multiple myeloma than in normal plasma cells. Treatment with a DOT1L inhibitor induced cell cycle arrest and apoptosis in myeloma cells, and strongly suppressed cell proliferation in vitro The anti-myeloma effect of DOT1L inhibition was confirmed in a mouse xenograft model.
DOI:
10.3324/haematol.2018.191262
