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Association details:
| Biomarker: | DNMT3A underexpression |
|---|---|
| Cancer: | Hepatocellular Cancer |
| Drug: | decitabine (DNMT inhibitor) |
| Direction: | Sensitive |
Evidence:
Title:
The Effect of 5-Aza-2'-Deoxycytidine in Combination to and in Comparison with Vorinostat on DNA Methyltransferases, Histone Deacetylase 1, Glutathione S-Transferase 1 and Suppressor of Cytokine Signaling 1 Genes Expression, Cell Growth Inhibition and Apoptotic Induction in Hepatocellular LCL-PI 11 Cell Line
Published date:
01/01/2020
Excerpt:
The result of qRT-PCR indicated that 5-Aza-CdR decreased DNMT1, DNMT3a, DNMT3b and increased GSTP1and SOCS1 genes expression and SAHA decreased HDAC1 and increased GSTP1 and SOCS1 genes expression significantly….by which inhibited cell viability and induced apoptosis,...
