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Association details:
| Biomarker: | DNMT1 rs2228611 |
|---|---|
| Cancer: | Colorectal Cancer |
| Drug: | Avastin (bevacizumab) (VEGF-A inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Impact of polymorphisms within genes involved in regulating DNA methylation in metastatic colorectal cancer patients enrolled in three independent, randomized, open-label clinical trials: a meta-analysis from TRIBE, MAVERICC, and FIRE-3
Excerpt:
A total of 884 mCRC patients from six treatment arms of three independent phase III trials....In the TRIBE FOLFIRI/bevacizumab (bev) arm, DNMT3A rs11681717, and TET1 rs3814177 had significant associations with OS (P=0.001, FDR=0.010), and TR (P=0.008, FDR=0.056), respectively...In the MAVERICC mFOLFOX6/bev arm, DNMT1 rs2228611 was significantly associated with TR (P=0.001, FDR=0.007).
Secondary therapy:
Modified FOLFOX6
DOI:
10.1016/j.ejca.2019.01.105
