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Association details:
| Biomarker: | DLGAP1-AS1 overexpression |
|---|---|
| Cancer: | Breast Cancer |
| Drug: | doxorubicin hydrochloride (Topoisomerase II inhibitor) |
| Direction: | Resistant |
Evidence:
Source:
Title:
N 6-methyladenosine (m 6 A)-mediated lncRNA DLGAP1-AS1enhances breast canceradriamycin resistance through miR-299-3p/WTAP feedback loop
Published date:
12/04/2021
Excerpt:
Here, our work shows that lncRNA DLGAP1 antisense RNA 1 (DLGAP1-AS1) is up-regulated in ADR-resistant BC cells (MCF-7/ADR). Clinically, higher DLGAP1-AS1 expression was closely correlated to poorer clinical prognosis. Results showed that DLGAP1-AS1 promoted the ADR IC50 and proliferation of ADR-resistant cells.
DOI:
10.1080/21655979.2021.2000198