^
Association details:
| Biomarker: | DKK4 overexpression |
|---|---|
| Cancer: | Colorectal Cancer |
| Drug: | AiTan (rivoceranib) (VEGFR-2 inhibitor) |
| Direction: | Resistant |
Evidence:
Source:
Title:
DKK4 enhances resistance to chemotherapeutics 5-Fu and YN968D1 in colorectal cancer cells
Excerpt:
In the present study, DKK4 was over expressed in several colorectal cancer cell lines...Analysis of cell viability in the control and DKK4 over-expressing cell lines, following treatment with 5-fluorouracil (5-Fu), YN968D1 or both, indicated that DKK4 over-expressing cells exhibit increased drug resistance.
DOI:
10.3892/ol.2016.5461
Source:
Title:
DKK4 enhances resistance to chemotherapeutics 5-Fu and YN968D1 in colorectal cancer cells
Excerpt:
In the present study, DKK4 was over expressed in several colorectal cancer cell lines...Analysis of cell viability in the control and DKK4 over-expressing cell lines, following treatment with 5-fluorouracil (5-Fu), YN968D1 or both, indicated that DKK4 over-expressing cells exhibit increased drug resistance.
Secondary therapy:
5-fluorouracil
DOI:
10.3892/ol.2016.5461
