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Association details:
Biomarker:DDR
Cancer:Melanoma
Drug Class:Immunotherapy
Direction:Sensitive
Evidence:
Evidence Level:
Sensitive: C3 – Early Trials
Source:
Title:

1640 - Correlations of DNA damage response gene alterations with response to immune checkpoint inhibitors are different in solid tumors

Published date:
03/10/2021
Excerpt:
DDR alterations are associated with ICIs efficacy in melanoma (P = 0.0007), colorectal cancer (P = 0.0012), NSCLC (P = 0.0224), bladder cancer (P = 0.0439), and breast cancer (P = 0.0451).