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Association details:
| Biomarker: | DDR |
|---|---|
| Cancer: | Hepatocellular Cancer |
| Regimen: | FOLFOX (5-fluorouracil + leucovorin calcium + oxaliplatin) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Analysis of DNA damage repair pathway genes as a predictive biomarker for HAIC in hepatocellular carcinoma.
Published date:
05/19/2021
Excerpt:
The survival analysis was performed on HCC patients treated with HAIC with FOLFOX...The progression-free survival (PFS) of DDR mutation group were significantly longer than wild-type group (median PFS, mutation vs. wild-type = 8.9 vs. 4.5 months; HR 0.34[95% CI 0.13-0.85]; P = 0.0349)....better treatment outcomes of HAIC with FOLFOX in DDR mutation HCC patients.
Secondary therapy:
Chemotherapy
