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Association details:
Biomarker:
CYP1A2 overexpression
Cancer:
Hepatocellular Cancer
Drug:
sorafenib
(
Multi-tyrosine kinase inhibitor
,
pan-RAF inhibitor
)
Direction:
Sensitive
Evidence:
Evidence Level:
Sensitive: D – Preclinical
Source:
AACR-II 2020
Title:
/ 16 - Omeprazole and sorafenib in combination reverses sorafenib-resistance by inhibiting NF-?B signaling in hepatocellular carcinoma
Published date:
05/15/2020
Excerpt:
MTT assay showed that the overexpression of CYP1A2 enhanced the sensitivity of SR cells against sorafenib and vice versa.
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