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Association details:
| Biomarker: | CYP1A2 overexpression |
|---|---|
| Cancer: | Hepatocellular Cancer |
| Drug: | sorafenib (Multi-tyrosine kinase inhibitor, pan-RAF inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
/ 16 - Omeprazole and sorafenib in combination reverses sorafenib-resistance by inhibiting NF-?B signaling in hepatocellular carcinoma
Published date:
05/15/2020
Excerpt:
MTT assay showed that the overexpression of CYP1A2 enhanced the sensitivity of SR cells against sorafenib and vice versa.