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Association details:
| Biomarker: | CYB5A rs1790834 |
|---|---|
| Cancer: | Prostate Cancer |
| Drug: | prednisone (Steroid receptor agonist) |
| Direction: | Resistant |
Evidence:
Source:
Title:
Association Between CYP17A1, CYB5A Polymorphisms and Efficacy of Abiraterone Acetate/Prednisone Treatment in Castration-Resistant Prostate Cancer Patients
Published date:
06/04/2020
Excerpt:
The SNP rs1790834 on CYB5A showed significant association with PSA response in CRPC patients treated with AA/P (P < 0.05), but rs743572, rs10883783 and rs1790858 did not. The rs1790834 variant significantly decreased both PFS and OS (P < 0.05)….The CYB5A rs790834 genotype is a novel SNP related to CRPC and may be used as a biomarker for CRPC treatment.
DOI:
10.2147/PGPM.S245086
