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Association details:
Biomarker:CXCL9 overexpression
Cancer:Ovarian Cancer
Drug Class:PD-L1 inhibitor
Direction:Sensitive
Evidence:
Evidence Level:
Sensitive: D – Preclinical
Title:

CXCL9 inhibits tumour growth and drives anti-PD-L1 therapy in ovarian cancer

Published date:
03/21/2022
Excerpt:
CXCL9 expression analysis in ovarian cancer subtypes and correlation to reported ICB response....CXCL9 overexpression resulted in T-cell accumulation, delayed ascites formation and improved survival, which was dependent on adaptive immune function….anti-PD-L1 treatment acted synergistically with Cxcl9 overexpression and significantly prolonged time to onset of ascites (median 51 vs. 45 days; P = 0.003) and overall survival (median 57 vs. 52 days; P = 0.007) in the Cxcl9+ tumour group (Fig. 2d).
DOI:
10.1038/s41416-022-01763-0