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Association details:
Biomarker:
CTNNB1 mutation
Cancer:
Endometrial Cancer
Drug:
everolimus
(
mTOR inhibitor
) +
letrozole
(
Aromatase inhibitor
)
Direction:
Sensitive
Evidence:
Evidence Level:
Sensitive: C3 – Early Trials
New
Source:
J Clin Oncol
Title:
Phase II Study of Everolimus and Letrozole in Patients With Recurrent Endometrial Carcinoma
Excerpt:
Patients with endometrioid histology and CTNNB1 mutations responded well to everolimus and letrozole.
DOI:
10.1200/JCO.2014.58.3401
Trial ID:
NCT01068249
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