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Association details:
| Biomarker: | CTNNB1 expression |
|---|---|
| Cancer: | Hepatocellular Cancer |
| Drug: | foscenvivint (PRI724) (CBP inhibitor, β-catenin inhibitor, Wnt signalling pathway inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Anti-tumor Activity of the Small Molecule Inhibitor PRI-724 Against ß-Catenin-activated Hepatocellular Carcinoma
Excerpt:
In HCC cell lines with a constitutively activated β-catenin, C-82 inhibited cell proliferation....Moreover, C-82 treatment significantly decreased the expression of cell proliferating markers and increased the expression of apoptosis-related proteins.
DOI:
10.21873/anticanres.14524
