^
Association details:
Biomarker:CSPG4 overexpression
Cancer:Soft Tissue Sarcoma
Drug:CSPG4.TNK (MCSP inhibitor)
Direction:Sensitive
Evidence:
Evidence Level:
Sensitive: D – Preclinical
Source:
Title:

CSPG4-specific CAR.CIK lymphocytes as a novel therapy for the treatment of multiple soft tissue sarcoma histotypes

Published date:
08/25/2020
Excerpt:
CSPG4 was highly expressed in multiple STS histotypes by in silico analysis and on all the 16 STS cell lines tested by flow cytometry. CSPG4-CAR.CIK displayed superior in vitro cytolytic activity against multiple STS histotypes as compared to paired unmodified control CIK....CSPG4-CAR.CIK significantly delayed or reversed tumor growth in vivo in three STS xenograft models (Leiomyosarcoma, UPS and Fibrosarcoma).
DOI:
10.1158/1078-0432.CCR-20-0357