^
Association details:
| Biomarker: | CSPG4 overexpression |
|---|---|
| Cancer: | Leiomyosarcoma |
| Drug: | CSPG4.TNK (MCSP inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
CSPG4-specific CAR.CIK lymphocytes as a novel therapy for the treatment of multiple soft tissue sarcoma histotypes
Published date:
09/08/2020
Excerpt:
CSPG4 was highly expressed in multiple STS histotypes by in silico analysis and on all the 16 STS cell lines tested by flow cytometry. CSPG4-CAR.CIK displayed superior in vitro cytolytic activity against multiple STS histotypes as compared to paired unmodified control CIK....CSPG4-CAR.CIK significantly delayed or reversed tumor growth in vivo in three STS xenograft models (Leiomyosarcoma, UPS and Fibrosarcoma).
DOI:
10.1158/1078-0432.CCR-20-0357
