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    Association details:
    Biomarker:CSMD3 mutation
    Cancer:Small Cell Lung Cancer
    Drug:etoposide oral (Topoisomerase II inhibitor, DNA inhibitor)
    Direction:Resistant
    Evidence:
    Evidence Level:
    Resistant: D – Preclinical
    Source:
    Drug Des Devel Ther
    Title:

    A novel mutation panel for predicting etoposide resistance in small-cell lung cancer

    Published date:
    06/21/2019
    Excerpt:
    ROC analysis of etoposide resistance revealed that the most significant single gene mutation indicating resistance to etoposide was CSMD3....study found that a panel with four genes (CSMD3, EPB41L3, PCLO, and RYR1) can accurately predict sensitivity to etoposide.
    DOI:
    10.2147/DDDT.S205633