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    Association details:
    Biomarker:CRTAC1 overexpression
    Cancer:Non Small Cell Lung Cancer
    Drug:cisplatin (DNA synthesis inhibitor)
    Direction:Sensitive
    Evidence:
    Evidence Level:
    Sensitive: D – Preclinical
    Source:
    SSRN
    Title:

    CRTAC1 Enhances the Chemosensitivity of Non-Small Cell Lung Cancer to Cisplatin Via Regulating Ca 2 /NFAT/STUB1/Akt1 Axis Induced-Apoptosis

    Published date:
    12/22/2022
    Excerpt:
    In vitro and in vivo functional experiments showed that CRTAC1 can significantly improve the sensitivity of NSCLC cells to cisplatin....CRTAC1 overexpression increases the chemosensitivity of NSCLC to cisplatin treatment by inducing Ca2+-dependent Akt1 degradation and apoptosis, suggesting the potential of CRTAC1 as a biomarker for predicting cisplatin chemosensitivity.
    DOI:
    http://dx.doi.org/10.2139/ssrn.4307634