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Association details:
| Biomarker: | CRIPTO expression |
|---|---|
| Cancer: | Colon Cancer |
| Drug: | BIIB015 (Microtubule inhibitor, Cripto-targeted antibody-drug conjugate) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
An antibody–cytotoxic conjugate, BIIB015, is a new targeted therapy for Cripto positive tumours
Excerpt:
The data presented here provide experimental evidence that BIIB015 is a potent targeted therapeutic molecule to directly kill Cripto positive tumour cells….BIIB015 specifically kills Cripto positive cells, in vitro and in vivo….In this experiment, mice bearing subcutaneous CT-3 colon tumour xenografts were treated with 20 mg/kg BIIB015 with or without a three-fold excess of naked huB3F6 (60 mg/kg). Treatment with BIIB015 alone inhibited tumour growth by 75–80%.
DOI:
https://doi.org/10.1016/j.ejca.2011.02.023
