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Association details:
| Biomarker: | CRIP1 overexpression |
|---|---|
| Cancer: | Multiple Myeloma |
| Drug: | bortezomib (Proteasome inhibitor) |
| Direction: | Resistant |
Evidence:
Source:
Title:
Critical roles of CRIP1 in promoting cell survival and bortezomib resistance by enhancing proteasome activity and autophagy in multiple myeloma
Published date:
09/10/2023
Excerpt:
Our data showed that CRIP1 was overexpressed in MM cells especially in patients with RRMM (relapsed/refractory MM). CRIP1 overexpression is linked to inferior outcome in patients with MM even those undergoing bortezomib (BTZ) treatment….In summary, CRIP1 was overexpressed in MM cells and correlated with inferior outcome of MM patients.