^
    Back
    Association details:
    Biomarker:COL3A1 overexpression
    Cancer:Lung Cancer
    Drug:cisplatin (DNA synthesis inhibitor)
    Direction:Resistant
    Evidence:
    Evidence Level:
    Resistant: D – Preclinical
    Source:
    Balkan Med J
    Title:

    COL3A1 Overexpression Associates with Poor Prognosis and Cisplatin Resistance in Lung Cancer

    Published date:
    11/07/2022
    Excerpt:
    We also observed a significantly higher COL3A1 expression in H460/DDP cells than in its lung cancer non-resistant H460 cells, suggesting that COL3A1 regulated lung cancer sensitivity to DDP. As expected, silencing COL3A1 increased the sensitivity of A549/ DDP and H1299/DDP to DDP, confirming that increased COL3A1 expression made the cancer cells more prone to DDP resistance.
    DOI:
    10.4274/balkanmedj.galenos.2022.2022-6-16