^
Association details:
Biomarker:CMTM6 overexpression
Cancer:Oral Cancer
Drug:cisplatin (DNA synthesis inhibitor)
Direction:Resistant
Evidence:
Evidence Level:
Resistant: D – Preclinical
Title:

CMTM6 drives cisplatin resistance by regulating Wnt signaling through ENO-1/AKT/GSK3ß axis

Published date:
01/12/2021
Excerpt:
Analyses of OSCC patient tumor samples demonstrated significantly higher CMTM6 expression in chemotherapy-non-responders as compared to responder...upon CMTM6 overexpression in CMTM6KD lines, the cisplatin resistant phenotype was efficiently rescued.
DOI:
10.1172/jci.insight.143643