^
Association details:
| Biomarker: | CMTM6 overexpression |
|---|---|
| Cancer: | Oral Cancer |
| Drug: | cisplatin (DNA synthesis inhibitor) |
| Direction: | Resistant |
Evidence:
Source:
Title:
CMTM6 drives cisplatin resistance by regulating Wnt signaling through ENO-1/AKT/GSK3ß axis
Published date:
01/12/2021
Excerpt:
Analyses of OSCC patient tumor samples demonstrated significantly higher CMTM6 expression in chemotherapy-non-responders as compared to responder...upon CMTM6 overexpression in CMTM6KD lines, the cisplatin resistant phenotype was efficiently rescued.
DOI:
10.1172/jci.insight.143643
