^
Association details:
Biomarker:CLDN6 positive
Cancer:Soft Tissue Sarcoma
Drug Class:T-lymphocyte cell therapy
Direction:Sensitive
Evidence:
Evidence Level:
Sensitive: C3 – Early Trials
Source:
Title:

BNT211: A phase I/IIa trial to evaluate safety and efficacy of CLDN6 CAR-T and CARVac-based in vivo expansion to improve treatment of patients with CLDN6-positive advanced solid tumors

Published date:
05/07/2021
Excerpt:
Patients with CLDN6-positive relapsed or refractory solid tumors...The underlying diseases of the first three patients were ovarian carcinoma, desmoplastic round small cell tumor and yolk sac carcinoma….In case of patient 2, stable disease with evidence of tumor shrinkage (-19.7%, target lesions) is observed.