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Association details:
| Biomarker: | CLDN18.2 overexpression |
|---|---|
| Cancer: | Gastric Cancer |
| Drug: | BMS-986476 (Microtubule inhibitor, CLDN18.2-targeted antibody-drug conjugate) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Preclinical activity for TPX-4589 (LM-302), an antibody-drug conjugate targeting tight junction protein CLDN18.2 in solid tumors
Published date:
10/12/2022
Excerpt:
Preclinical studies were conducted to characterize TPX-4589 in CLDN18.2-positive cells....In a cell-line xenograft GC tumor model with high CLDN18.2 expression, TPX-4589 significantly reduced tumor volume in a dose-dependent manner and demonstrated superior efficacy to zolbetuximab.
