ASP2138 showed cytotoxicity against CLDN18.2-expressing gastric or pancreatic cancer cells...SP2138 exhibited an antitumor effect on human CLDN18.2-expressing gastric cancer in a human PBMC-engrafted NOG mouse model in vivo. In summary, ASP2138 is expected to show a clinical effect through cytotoxicity against CLDN18.2-expressing tumor cells...