^
Association details:
| Biomarker: | CIC deletion |
|---|---|
| Cancer: | Pancreatic Cancer |
| Drug: | Mekinist (trametinib) (MEK inhibitor) |
| Direction: | Resistant |
Evidence:
Source:
Title:
ATXN1L, CIC, and ETS Transcription Factors Modulate Sensitivity to MAPK Pathway Inhibition
Excerpt:
Indeed, trametinib treated CICKO tumors grew at comparable rates to vehicle-treated CICWT or CICKO tumors (Figure 3H). Based on these observations, we concluded that CICKO reduces sensitivity to trametinib treatment in vivo.
DOI:
10.1016/j.celrep.2017.01.031
