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Association details:
| Biomarker: | Chr t(4;11)(q21;q23) |
|---|---|
| Cancer: | B Acute Lymphoblastic Leukemia |
| Drug: | Blincyto (blinatumomab) (CD3 agonist, CD19 inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Updated Results from the Phase II Study of Hyper-CVAD in Sequential Combination with Blinatumomab in Newly Diagnosed Adults with B-Cell Acute Lymphoblastic Leukemia (B-ALL)
Published date:
11/06/2019
Excerpt:
Twenty (74%) pts had CD20+ expression. Fifteen (56%) pts had high-risk features at baseline: 9 (33%) with TP53 mutation, 4 (15%) with Ph-like, 5 (19%) with Ho-Tr, 1 (4%) with t(4;11) and 1 (4%) with complex karyotype….The sequential combination of Hyper-CVAD and Blina in newly diagnosed B-ALL is safe and highly effective. This regimen produced CR in all pts and MRD eradication in 96% of pts. The preliminary survival outcomes are favorable.
DOI:
https://doi.org/10.1182/blood-2019-129657
