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    Association details:
    Biomarker:Chr t(22)
    Cancer:Germ Cell Tumors
    Drug:cisplatin (DNA synthesis inhibitor) +
    ifosfamide (Bifunctional alkylating agent) +
    etoposide oral (Topoisomerase II inhibitor, DNA inhibitor) +
    mesna (Antioxidant)
    Direction:Sensitive
    Evidence:
    Evidence Level:
    Sensitive: C4 – Case Studies
    New
    Source:
    Tumori
    Title:

    Primitive neuroectodermal tumor (PNET) as somatic-type malignancy arising from an extragonadal germ-cell tumor: clinical, pathological and molecular features of a case

    Excerpt:
    We report a rare case of a 34-year-old man...with a secondary somatic malignancy arising in the background of nonseminomatous germ-cell tumor, teratoma, yolk sac tumor, and primitive neuroectodermal tumor with distinct chromosome 22 translocation. Although the patient initially responded well to chemotherapy with etoposide, cisplatin, ifosfamide and mesna, he relapsed shortly after.
    DOI:
    10.1700/1248.13807