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Association details:
| Biomarker: | Chr t(22) |
|---|---|
| Cancer: | Germ Cell Tumors |
| Drug: | cisplatin (DNA synthesis inhibitor) + ifosfamide (Bifunctional alkylating agent) + etoposide oral (Topoisomerase II inhibitor, DNA inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Primitive neuroectodermal tumor (PNET) as somatic-type malignancy arising from an extragonadal germ-cell tumor: clinical, pathological and molecular features of a case
Excerpt:
We report a rare case of a 34-year-old man...with a secondary somatic malignancy arising in the background of nonseminomatous germ-cell tumor, teratoma, yolk sac tumor, and primitive neuroectodermal tumor with distinct chromosome 22 translocation. Although the patient initially responded well to chemotherapy with etoposide, cisplatin, ifosfamide and mesna, he relapsed shortly after.
DOI:
10.1700/1248.13807
