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Association details:
| Biomarker: | Chr del(1p)+ Chr del(19q) |
|---|---|
| Cancer: | Glioma |
| Drug: | temozolomide (DNA synthesis inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
IDH1 or IDH2 mutations predict longer survival and response to temozolomide in low-grade gliomas
Excerpt:
IDH mutation and 1p-19q codeletion were associated with prolonged overall survival in univariate (p=0.002 and p=0.0001) and multivariate analysis (p=0.003 and p=0.004). 1p-19q codeletion, MGMT promoter methylation, and IDH mutation (p=0.01) were correlated with a higher rate of response to temozolomide.
DOI:
10.1212/WNL.0b013e3181f96282
Source:
Title:
Correlation of Molecular Markers in High Grade Gliomas with Response to Chemo-Radiation
Excerpt:
The 20-months PFS for different mutations were as follows; IDH1-mutated vs wild type: 53.6% vs 29.8%; p-0.035, 1p/19q codeleted vs non-codeleted: 85.7% vs 62.3%; p-0.011, p53 wild type vs mutated 32.1% vs 35.6%; p-0.035 and ATRX lost vs retained: 55.6% vs 53.3%; p- 0.369. The 20-months OS for IDH1 mutated vs wild type: 82.4% vs 30.6%; p-0.014, 1p/19q codeleted vs non-codeleted: 85.7% vs 65.8%; p-0.104, p53 wild-type vs mutated 45.5% vs 73.9%; p-0.036 and ATRX lost vs retained: 100% vs 60.3%; p-0.087. there was significant PFS improvement (85.7% vs 62.3%, p-0.01) with 1p/19q codeletion.
