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Association details:
| Biomarker: | Chr del(17p) |
|---|---|
| Cancer: | Leukemia |
| Drug: | Darzalex (daratumumab) (CD38 inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
1913 Improved Survival of Patients with Primary Plasma Cell Leukemia with VRD or Daratumumab-Based Quadruplets: A Multicenter Study By the Greek Myeloma Study Group
Published date:
11/03/2022
Excerpt:
We analyzed the medical records of 110 pPCL patients....In the univariate analysis, ECOG ≥2, PLT <100.000/μL, cPCs (5-20% vs >20%), del17p(+), upfront treatment with VRd/DBQ, ASCT and CR were independent prognostic factors for OS; treatment with VRd/DBQ, del17p(+) and PLT <100.000/μL, significantly predicted for OS in the multivariate analysis (p<0.05).
DOI:
https://doi.org/10.1182/blood-2022-163065
