In this phase 1b study, zanubrutinib was tolerable at 160 mg twice daily or 320 mg once daily combined with IV obinutuzumab in patients with CLL/SLL (n = 45) and FL (n = 36). At a median follow-up of 29 months (range, 8-37) for patients with TN CLL/SLL, overall response rate (ORR) was 100% (n = 20), including 6 CRs (30%); for patients with R/R CLL/SLL, ORR was 92% (n = 23), including 7 CRs (28%). Of 16 patients with del(17p), 6 (100%) of 6 TN patients and 8 (80%) of 10 R/R patients had an objective response...with 50% and 20% achieving CR, respectively.