Eligible pts with R/R CLL/SLL...19 pts received liso-cel (DL1, n = 4; DL2, n = 15) with ibr....18 pts (95%) had high-risk cytogenetics (del[17p], n = 8; TP53 mutation, n = 6; complex karyotype [≥3 chromosomal aberrations], n = 8)....Of 19 pts with ≥1-mo follow-up, 18 (95%) had an objective response; 12 (63%) had a CR/CRi. One pt (5%) had stable disease...and 16 of 18 pts (89%) have ongoing responses at ≥6 mo.