^
Association details:
| Biomarker: | Chr del(13q) |
|---|---|
| Cancer: | Multiple Myeloma |
| Drug: | bortezomib (Proteasome inhibitor) |
| Direction: | Resistant |
Evidence:
Source:
Title:
Downregulated miR-33b is a novel predictor associated with disease progression and poor prognosis in multiple myeloma
Excerpt:
...patients with del(13q), del(17p), t(4;14) and high-risk genetic abnormalities have lower expression levels of miR-33b compared to patients without those of abnormalities (p = 0.032, 0.018, 0.034, 0.005). Survival analysis showed patients with miR-33b low expression had significantly shortened PFS (p = 0.016) and OS (p = 0.033) and might be associated with drug resistance to bortezomib-based treatment.
DOI:
https://doi.org/10.1016/j.leukres.2015.04.010
