^
Association details:
| Biomarker: | Chr del(11q) |
|---|---|
| Cancer: | Chronic Lymphocytic Leukemia |
| Drug: | dorsomorphin (Compound C) (AMPK inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Targeting Autophagy Triggers Apoptosis and Complements the Action of Venetoclax in Chronic Lymphocytic Leukemia Cells
Published date:
09/10/2021
Excerpt:
The AMPK inhibitor dorsomorphin, the ULK1/2 inhibitor MRT68921, and the autophagosome-lysosome fusion inhibitor chloroquine demonstrated concentration-dependent and time-dependent cytotoxicity against CLL cells, even in those from hard-to-treat patients who carried del(11q) and del(17p).
Secondary therapy:
hydroxychloroquine
DOI:
10.3390/cancers13184557
