^
Association details:
| Biomarker: | CENPI overexpression |
|---|---|
| Cancer: | Glioma |
| Drug: | Zejula (niraparib) (PARP inhibitor) |
| Direction: | Resistant |
Evidence:
Source:
Title:
Loss of CENP-I Impairs Homologous Recombination and Sensitizes Cells to PARP1 Inhibition
Published date:
06/26/2021
Excerpt:
...cellular survival after ionizing radiation and Niraparib, a PARP1 small molecule inhibitor, exposures...Importantly, CENP-I expression is elevated in glioma tissue as compared to normal brain tissue. This elevated expression also correlates with poor overall patient survival.
DOI:
10.3390/cancers13133202
