^
Association details:
Evidence:
Evidence Level:
Sensitive: D – Preclinical
Source:
Title:

p16 INK4A-deficiency predicts response to combined HER2 and CDK4/6 inhibition in HER2+ breast cancer brain metastases

Published date:
03/18/2022
Excerpt:
We report that the tumor suppressor p16INK4A is deficient in the majority of HER2+ BCBMs. p16INK4A-deficiency as measured by protein immunohistochemistry predicted response to combined tucatinib and abemaciclib in orthotopic patient-derived xenografts (PDXs) of HER2 + BCBMs.
DOI:
10.1038/s41467-022-29081-2