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    Association details:
    Biomarker:CDK9 overexpression
    Cancer:Uveal Melanoma
    Drug:SNS-032 (CDK inhibitor)
    Direction:Sensitive
    Evidence:
    Evidence Level:
    Sensitive: D – Preclinical
    New
    Source:
    Mol Cancer
    Title:

    Transcriptional inhibition by CDK7/9 inhibitor SNS-032 abrogates oncogene addiction and reduces liver metastasis in uveal melanoma

    Published date:
    09/16/2019
    Excerpt:
    The results showed that CDK7/9 were highly expressed in UM cells, and SNS-032 significantly suppressed the cellular proliferation, induced apoptosis, and inhibited the outgrowth of xenografted UM cells and PDX tumors in NOD-SCID mice
    DOI:
    https://doi.org/10.1186/s12943-019-1070-7